Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

14.7K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

3.1K
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan...
3.1K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.6K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

944
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
944

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to: Antibiotics and hexagonal order in the bacterial outer membrane.

Nature communications·2023
Same author

Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae.

Science advances·2023
Same author

Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane.

Nature communications·2022
Same author

Anti-biofilm activity of murepavadin against cystic fibrosis Pseudomonas aeruginosa isolates.

The Journal of antimicrobial chemotherapy·2021
Same author

Macrocycle Therapeutics to Treat Life-threatening Diseases.

Chimia·2021
Same author

Emerging peptide antibiotics with therapeutic potential.

Medicine in drug discovery·2021

Related Experiment Video

Updated: Feb 23, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.5K

Advances in macrocyclic peptide-based antibiotics.

Anatol Luther1, Christian Bisang1, Daniel Obrecht1

  • 1Polyphor Ltd, Hegenheimermattweg 125, CH-4123 Allschwil, Switzerland.

Bioorganic & Medicinal Chemistry
|September 10, 2017
PubMed
Summary

Novel macrocyclic peptides show potent activity against Gram-negative pathogens, offering new hope against antibiotic resistance. These compounds provide promising scaffolds for developing urgently needed antibiotics targeting challenging bacterial infections.

Keywords:
AntibioticsGram-negative ESKAPE pathogensMacrocyclic peptides and depsipetidesOuter-membrane protein targeting antibiotics (OMPTA)

More Related Videos

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

3.2K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.9K

Related Experiment Videos

Last Updated: Feb 23, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.5K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

3.2K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.9K

Area of Science:

  • Medicinal Chemistry
  • Microbiology
  • Natural Products

Background:

  • Macrocyclic peptides from natural products are valuable sources for antibiotic drug discovery.
  • Existing macrocyclic peptides primarily target Gram-positive bacteria.
  • There is a critical need for new antibiotics effective against Gram-negative pathogens.

Purpose of the Study:

  • To review recent advancements in macrocyclic peptide-based compounds.
  • To highlight novel compounds with activity against Gram-negative ESKAPE pathogens.
  • To discuss the potential of these compounds as antibiotic scaffolds.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of reported activities of novel macrocyclic peptide-based compounds.
  • Focus on compounds targeting ESKAPE pathogens.

Main Results:

  • Identification of novel macrocyclic peptide-based compounds.
  • Demonstration of potent and specific activity against Gram-negative ESKAPE pathogens.
  • These compounds represent a new class of antibiotics.

Conclusions:

  • Novel macrocyclic peptides offer a promising avenue for combating Gram-negative bacterial infections.
  • These compounds can serve as scaffolds for developing next-generation antibiotics.
  • Continued research is crucial for addressing antimicrobial resistance.