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Cell therapies for Chagas disease

Adriana Bastos Carvalho1, Regina Coeli Dos Santos Goldenberg1, Antonio Carlos Campos de Carvalho1

  • 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Centro Nacional de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, Rio de Janeiro, Brazil.

Cytotherapy
|September 10, 2017
PubMed

Insights

Cell therapies offer a promising alternative for treating Chagas disease, particularly chronic chagasic cardiomyopathy. This review examines preclinical and clinical trials exploring cell-based treatments for this severe condition.

Area of Science:

  • Cardiology
  • Immunology
  • Regenerative Medicine

Background:

  • Chagas disease affects millions globally, with chronic chagasic cardiomyopathy being a severe, lethal manifestation.
  • Current treatments for Chagas disease are limited, especially for advanced cardiac complications.

Purpose of the Study:

  • To review the current landscape of cell therapies for Chagas disease.
  • To analyze preclinical and clinical trial data on cell-based treatments for chronic chagasic cardiomyopathy.

Main Methods:

  • Comprehensive literature search of preclinical and clinical studies on cell therapies in Chagas disease.
  • Analysis of study designs, cell types used, therapeutic outcomes, and safety profiles.

Main Results:

  • Various cell types, including mesenchymal stem cells and induced pluripotent stem cells, have shown potential in preclinical models.
  • Early-phase clinical trials are exploring the safety and efficacy of cell therapies in patients with chronic chagasic cardiomyopathy.

Conclusions:

  • Cell therapies represent a promising avenue for managing chronic chagasic cardiomyopathy.
  • Further rigorous clinical trials are needed to establish the definitive role of cell therapies in Chagas disease treatment.

Keywords:
Chagas diseasebone marrow cellscardiomyopathycell therapymesenchymal stromal cells

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