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Related Experiment Video

Updated: Feb 23, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Trabecular Meshwork Height in Primary Open-Angle Glaucoma Versus Primary Angle-Closure Glaucoma.

Marisse Masis1, Rebecca Chen1, Travis Porco1

  • 1Department of Ophthalmology, University of California, San Francisco, San Francisco, California.

American Journal of Ophthalmology
|September 10, 2017
PubMed
Summary

Trabecular meshwork (TM) height is significantly shorter in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes. This finding may aid in diagnosing and managing angle-closure glaucoma.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Anatomy

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) are distinct subtypes with different pathophysiologies.
  • The trabecular meshwork (TM) plays a crucial role in aqueous humor outflow and intraocular pressure regulation.

Purpose of the Study:

  • To investigate and compare the trabecular meshwork (TM) height between eyes diagnosed with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG).
  • To determine if anatomical differences in TM height exist between these two major glaucoma subtypes.

Main Methods:

  • A prospective, cross-sectional clinical study involving adult patients from glaucoma clinics.
  • Spectral-domain optical coherence tomography (OCT) was used to obtain high-resolution images of the anterior segment.
  • Univariate and multivariate linear mixed models were employed to analyze TM height in relation to glaucoma type, adjusting for potential confounders.

Main Results:

  • The study included 260 eyes from 161 patients (mean age 70 years).
  • Mean TM height was significantly shorter in the PACG group (732 ± 27 μm) compared to the POAG group (812 ± 13 μm).
  • This difference remained statistically significant in both univariate (P = .004) and multivariate analyses (β = -88.7; P = .008).

Conclusions:

  • Trabecular meshwork height is demonstrably shorter in patients with primary angle-closure glaucoma compared to those with primary open-angle glaucoma.
  • This anatomical difference may offer insights into the underlying mechanisms of angle closure.
  • The findings could potentially assist in the future diagnosis, prevention, and management strategies for angle-closure disorders.