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Updated: Feb 23, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Cold stress-induced ferroptosis involves the ASK1-p38 pathway.

Kazuki Hattori¹, Hiroyuki Ishikawa¹, Chihiro Sakauchi¹

¹The Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

|September 10, 2017

Summary

Severe cold stress triggers ferroptosis, a form of regulated necrosis, by activating the ASK1-p38 MAPK pathway. This pathway

Keywords:

ASK1 cold stress ferroptosis p38 MAPK

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Area of Science:

Cellular biology
Molecular mechanisms of cell death
Biochemistry

Background:

Ferroptosis is a critical cell death pathway implicated in various diseases.
The precise molecular drivers of ferroptosis remain incompletely understood.
Understanding cell death mechanisms is crucial for disease research.

Purpose of the Study:

To elucidate the molecular mechanisms underlying ferroptosis induction.
To investigate the role of the ASK1-p38 MAPK pathway in cold-induced ferroptosis.
To explore the relationship between ferroptosis inducers and the ASK1-p38 axis.

Main Methods:

Induction of ferroptosis using severe cold stress in multiple cell lines.
Analysis of the ASK1-p38 MAPK pathway activation.
Investigation of key ferroptosis determinants: MEK activity, iron ions, and lipid peroxide.
Treatment with erastin, a known ferroptosis inducer.

Main Results:

Continuous severe cold stress was shown to induce ferroptosis.
The ASK1-p38 MAPK pathway was activated by cold stress, mediated by MEK activity, iron, and lipid peroxide.
Erastin also activated the ASK1-p38 axis downstream of lipid peroxidation.
ASK1-dependent cell death was observed in a cell type-specific manner.

Conclusions:

Severe cold stress is a novel inducer of ferroptosis via the ASK1-p38 MAPK pathway.
This study provides mechanistic insights into ferroptosis regulation.
The findings highlight the cell type-specific roles of ASK1 in ferroptosis.