Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.2K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

17.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
17.3K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.3K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

6.7K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
6.7K
Inflammatory Response01:28

Inflammatory Response

17.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practicing Medicine at Life's Discontinuities.

Stroke (Hoboken, N.J.)·2026
Same author

Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure: The RAFT Clinical Trial.

JAMA·2026
Same author

Does early gastrostomy tube placement after stroke improve functional recovery and quality of life? A literature-informed pathway-decomposition analysis.

Neurological research·2026
Same author

Corticospinal tract risk modifies motor recovery after minimally invasive surgery for intracerebral hemorrhage: a secondary analysis of MISTIE-III.

medRxiv : the preprint server for health sciences·2026
Same author

Microthrombi and hypercoagulability's contribution to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Real-World Safety Profile of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: a Multinational Multicenter Study.

Clinical neuroradiology·2026

Related Experiment Video

Updated: Feb 23, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.5K

CSF inflammatory response after intraventricular hemorrhage.

Maged D Fam1, Hussein A Zeineddine1, Javed Khader Eliyas1

  • 1From the Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery (M.D.F., H.A.Z., J.K.E., A.S., M.J., Y.C., M.W., L.Z., Y.C., M.W., L.Z., I.A.A.), University of Chicago Medicine and Biological Sciences, IL; Brain Injury Outcomes (BIOS) Division, Department of Neurology (N.M., K.L., W.Z., D.F.H.), and The Bloomberg School of Public Health (R.E.T.), Johns Hopkins University Medical Institutions, Baltimore, MD; and Department of Neurology (S.J.), Rush University Medical Center, Chicago, IL.

Neurology
|September 10, 2017
PubMed
Summary
This summary is machine-generated.

Cerebrospinal fluid (CSF) inflammation after intraventricular hemorrhage (IVH) depends on bleed volume. Thrombolysis increases inflammation but does not worsen patient outcomes.

More Related Videos

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:20

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

637
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
10:44

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase

Published on: September 22, 2012

25.6K

Related Experiment Videos

Last Updated: Feb 23, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

3.5K
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
04:20

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

637
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
10:44

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase

Published on: September 22, 2012

25.6K

Area of Science:

  • Neurology
  • Critical Care Medicine
  • Neuroinflammation

Background:

  • Intraventricular hemorrhage (IVH) is a severe condition often leading to neuroinflammation.
  • Understanding the dynamics of cerebrospinal fluid (CSF) inflammatory markers is crucial for managing IVH patients.

Purpose of the Study:

  • To analyze the temporal patterns of CSF inflammatory measures following IVH.
  • To identify factors associated with these inflammatory responses.
  • To determine the impact of inflammation on clinical outcomes.

Main Methods:

  • Analysis of prospectively collected CSF data (cell counts, protein, glucose) from the CLEAR III trial.
  • Calculation of corrected leukocyte counts and cell indices.
  • Correlation of CSF inflammatory measures with IVH volume, clearance, thrombolysis, infection, and clinical outcomes.

Main Results:

  • CSF inflammatory response evolved during IVH resolution, particularly with larger initial bleed volumes (>20 mL).
  • Intraventricular alteplase significantly increased CSF inflammation compared to saline.
  • CSF inflammation showed a non-predictive correlation with bacterial infection.
  • No significant detrimental effect on 30 or 180-day outcomes or mortality was observed.

Conclusions:

  • Aseptic CSF inflammation post-IVH is primarily driven by initial hemorrhage volume.
  • Thrombolysis intensifies the inflammatory response without negatively impacting clinical outcomes.