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Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Prevention of Further Absorption of Poison01:14

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
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Child with Vomiting.

Madhusudan Samprathi1, Muralidharan Jayashree2

  • 1Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Indian Journal of Pediatrics
|September 10, 2017
PubMed
Summary
This summary is machine-generated.

Vomiting in children often has benign causes like infections, but serious conditions require prompt recognition. A thorough history and physical exam are key to distinguishing between harmless and dangerous vomiting in pediatric patients.

Keywords:
AntiemeticsChildrenVomiting

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Emergency Medicine

Background:

  • Vomiting is a frequent pediatric concern prompting healthcare consultations.
  • Etiologies range from benign to life-threatening systemic diseases.
  • Gastrointestinal and non-gastrointestinal infections are common causes.

Purpose of the Study:

  • To differentiate benign from sinister causes of pediatric vomiting.
  • To outline diagnostic approaches including history and physical examination.
  • To guide management strategies for pediatric vomiting.

Main Methods:

  • Detailed patient history taking.
  • Meticulous physical examination, including vital signs, hydration status, abdominal assessment, and fundoscopy.
  • Identification of 'red flag' symptoms indicating serious conditions.
  • Consideration of investigations like abdominal X-ray for suspected obstruction.

Main Results:

  • Benign, self-limiting causes are most frequent.
  • Key red flags include unstable vitals, acidotic breathing, bile/blood-stained vomitus, GI obstruction signs, encephalopathy, and papilledema.
  • Physical exam components like abdominal and fundal examination are crucial.

Conclusions:

  • Distinguishing benign from sinister vomiting relies on thorough clinical assessment.
  • Prompt recognition of red flags and underlying causes is vital for appropriate management.
  • Symptomatic treatment alone may delay diagnosis; observation or admission may be necessary for unclear cases.