Effects of NO₂ exposure on daily mortality in São Paulo, Brazil

Recent reports have suggested that air pollution mixtures represented by nitrogen dioxide (NO₂) may have effects on human health, which are independent from those of particulate matter mass. We evaluate the association between NO₂ and daily mortality among elderly using one- and multipollutant models.

This study was a daily time series of non-accidental and cause-specific mortality among the elderly living in São Paulo, Brazil, between 2000 and 2011. Effects of NO₂, particulate matter smaller than 10µm (PM10), carbon monoxide (CO) and ozone (O₃) were estimated in Poisson generalized additive models. The single lag effect at lags 0 and 1 days and the cumulative effect from 0 to lag 10 days were evaluated in one-, two-, three- and four-pollutant models. The cumulative risk index (CRI) recently proposed to analyze associations with health of multiple correlated pollutants was additionally estimated for each multipollutant model.

An association between NO₂, PM10, CO and O₃ exposures and non-accidental and cause-specific deaths was found in one-pollutant models. NO₂ effects remained significant in multipollutant models for non-accidental and circulatory deaths. The estimated CRIs suggested that circulatory deaths were mainly associated with NO₂, and respiratory deaths mainly with CO and O₃, regardless the lag. For non-accidental deaths, multipollutant models were associated with the highest CRI, with the main pollutants depending on the chosen lag.

The results suggest that air pollution mixtures represented by NO₂ have an effect on non-accidental and circulatory mortality, which is independent from PM10, CO and O₃. The CRI was always larger than the risks associated with single pollutants.