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Updated: Feb 23, 2026
07:01
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
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Heterotopic Ossification and Hypertrophic Scars.
Shailesh Agarwal1, Michael Sorkin1, Benjamin Levi1
1Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA; Burn/Wound and Regenerative Medicine Laboratory, University of Michigan, Ann Arbor, MI, USA.
Clinics in Plastic Surgery
|September 11, 2017
Summary
Soft tissue wounds from burns and trauma often fail to heal properly, leading to complications like heterotopic ossification and hypertrophic scars. This review covers the management strategies for these challenging pathologic wounds.
Area of Science:
- Wound healing
- Tissue regeneration
- Pathologic wound management
Background:
- Burns and trauma result in soft tissue wounds that exhibit impaired healing capacity.
- Pathologic wound healing can manifest as heterotopic ossification or hypertrophic scars, causing significant pain and functional deficits.
Purpose of the Study:
- To review current management strategies for pathologic soft tissue wounds.
- To provide an overview of treatments for heterotopic ossification and hypertrophic scars.
Main Methods:
- Literature review of existing studies on wound healing and management.
- Synthesis of information on therapeutic interventions for specific pathologic wound types.
Main Results:
- Heterotopic ossification management involves radiation therapy, NSAIDs, bisphosphonates, and surgery.
- Hypertrophic scar treatment includes CO2 laser, steroid injections, and surgical excision with skin grafting.
Conclusions:
- Effective management of pathologic wounds requires tailored therapeutic approaches.
- Addressing complications like heterotopic ossification and hypertrophic scars is crucial for restoring function and improving patient outcomes.
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