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Published on: December 16, 2021
miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway
Jiangtao Hou1, Xueying Hu2, Bin Chen1
1Department of Gastroenterology, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510000, China.
Background:
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) affecting millions of people worldwide. miR-155 has been reported to be upregulated in various inflammatory diseases and is a positive regulator of the T-cell response. IL-17 secreting helper T (Th17) cells have been heavily implicated in tissue-specific immune pathology, including UC.
Methods And Results:
Therefore, we targeted miR-155 and investigated its expression levels in a DSS-induced UC mouse model, revealing increased expression. Est-1 expression was found to have decreased, but the levels of IL-23/17/6 were raised significantly and Th17 had experienced an obvious increase. We overexpressed miR-155 using a lentiviral treatment. Increased miR-155 expression induced a more severe damage to colon tissues. In this case, the level of Est-1 decreased even further, thereby enhancing IL-23/17/6-mediated Th17 differentiation.
Conclusion:
miR-155 seems to target Est-1 and induces UC via the IL-23/17/6-mediated Th17 pathway.
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