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Increased insulin resistance in men with unexplained infertility
Ragaa Mansour1, Yahia El-Faissal2, Ahmed Kamel2
1The Egyptian IVF-ET Centre, 11431 Cairo, Egypt.
Reproductive Biomedicine Online
|September 11, 2017
Summary
Insulin resistance (IR) is more prevalent in men with unexplained infertility, potentially causing reproductive and metabolic issues. Further research into insulin-sensitizing agents is recommended for these patients.
Area of Science:
- Reproductive Endocrinology
- Metabolic Syndrome
Background:
- Insulin resistance (IR) is a metabolic condition affecting glucose regulation.
- Unexplained infertility in men is a significant clinical challenge.
- The link between IR and male infertility requires further investigation.
Purpose of the Study:
- To investigate the prevalence of insulin resistance (IR) in men diagnosed with unexplained infertility.
- To compare metabolic and hormonal profiles between infertile men and fertile controls.
Main Methods:
- A prospective case-control study was conducted.
- 160 infertile men with oligozoospermia and 79 fertile men were included.
- Fasting blood tests measured insulin, FSH, LH, lipids, and IR.
Main Results:
- Infertile men exhibited significantly higher insulin levels and IR compared to controls (P < 0.0001).
- Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were significantly elevated in the infertile group (P < 0.0001).
- Total cholesterol levels were also significantly higher in infertile men (P < 0.05).
Conclusions:
- Insulin resistance may contribute to reproductive and metabolic abnormalities in men with unexplained infertility.
- The findings suggest a potential role for IR in male reproductive health.
- Investigating insulin-sensitizing agents for this patient group is warranted.
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