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Characterization of the activity of a platelet activating factor antagonist, CV-3988
M Hayashi1, J Kimura, S Oh-Ishi
1Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Japanese Journal of Pharmacology
|June 1, 1987
Abstract:
CV-3988 inhibited the vascular permeability increase induced by C16-PAF and C18-PAF in rat skin in a dose-dependent manner. The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: parallel shift of the dose-response curve; crossing of double reciprocal plots on the intersection of the ordinate; and no inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC4. PAF-induced blood pressure fall in rats was also suppressed by pretreatment with CV-3988 selectively.