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Related Experiment Video

Updated: Feb 23, 2026

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

Manganese and Developmental Neurotoxicity.

Roberto Lucchini^1,2, Donatella Placidi³, Giuseppa Cagna³

¹Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. roberto.lucchini@mssm.edu.

Advances in Neurobiology

|September 11, 2017

Summary

This summary is machine-generated.

Environmental manganese (Mn) exposure can harm brain development, especially in children, potentially causing Parkinson-like symptoms and affecting cognitive functions. Research is exploring sources and biomarkers for prevention strategies.

Keywords:

Basal ganglia Deposited dust Fungicides Methylcyclopentadienyl Mn tricarbonyl (MMT)Olfactory loss Revised Conners’ Teacher Rating Scale Vehicle emissions Wechsler Intelligence Scale for Children (WISC)

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Area of Science:

Neuroscience
Environmental Health
Toxicology

Background:

Manganese (Mn) is vital for brain function but environmental overexposure can lead to neurotoxicity.
Accumulation in the basal ganglia is linked to Parkinson-like disorders.
Early-life exposure is a growing concern, potentially impacting cognitive and executive functions via the frontal cortex.

Purpose of the Study:

To review environmental sources of manganese exposure.
To explore mechanisms of developmental neurotoxicity.
To identify biomarkers for early detection of exposure and functional alterations.

Main Methods:

Literature review of environmental manganese exposure.
Analysis of neurotoxicity mechanisms in developmental stages.
Examination of biomarkers for manganese-related neurodevelopmental issues.

Main Results:

Environmental manganese exposure poses risks to brain development, particularly in early life.
Overexposure can lead to Parkinson-like symptoms and affect cognitive functions.
Identifying exposure sources and biomarkers is crucial for prevention.

Conclusions:

Understanding developmental neurotoxicity of manganese is essential for public health.
Preventive strategies require knowledge of environmental sources and early biomarkers.
Further research is needed to mitigate risks associated with environmental manganese exposure.