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Manganese and Developmental Neurotoxicity

Roberto Lucchini1,2, Donatella Placidi3, Giuseppa Cagna3

  • 1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. roberto.lucchini@mssm.edu.

Advances in Neurobiology
|September 11, 2017
PubMed

Insights

Environmental manganese (Mn) exposure can harm brain development, especially in children, potentially causing Parkinson-like symptoms and affecting cognitive functions. Research is exploring sources and biomarkers for prevention strategies.

Area of Science:

  • Neuroscience
  • Environmental Health
  • Toxicology

Background:

  • Manganese (Mn) is vital for brain function but environmental overexposure can lead to neurotoxicity.
  • Accumulation in the basal ganglia is linked to Parkinson-like disorders.
  • Early-life exposure is a growing concern, potentially impacting cognitive and executive functions via the frontal cortex.

Purpose of the Study:

  • To review environmental sources of manganese exposure.
  • To explore mechanisms of developmental neurotoxicity.
  • To identify biomarkers for early detection of exposure and functional alterations.

Main Methods:

  • Literature review of environmental manganese exposure.
  • Analysis of neurotoxicity mechanisms in developmental stages.
  • Examination of biomarkers for manganese-related neurodevelopmental issues.

Main Results:

  • Environmental manganese exposure poses risks to brain development, particularly in early life.
  • Overexposure can lead to Parkinson-like symptoms and affect cognitive functions.
  • Identifying exposure sources and biomarkers is crucial for prevention.

Conclusions:

  • Understanding developmental neurotoxicity of manganese is essential for public health.
  • Preventive strategies require knowledge of environmental sources and early biomarkers.
  • Further research is needed to mitigate risks associated with environmental manganese exposure.
Keywords:
Basal gangliaDeposited dustFungicidesMethylcyclopentadienyl Mn tricarbonyl (MMT)Olfactory lossRevised Conners’ Teacher Rating ScaleVehicle emissionsWechsler Intelligence Scale for Children (WISC)

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