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Analysis of Point Mutations in Clinical Samples of Urothelial Carcinoma

Mustafa Alamyar1, Ellen C Zwarthoff2

  • 1Department of Pathology, Erasmus MC, PO Box2040, 3000 CA, Rotterdam, The Netherlands.

Methods in Molecular Biology (Clifton, N.J.)
|September 11, 2017
PubMed

Keywords:
DNA isolationFGFR3Mutation analysisOncogenic mutationsPIK3CARASTERT

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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