Related Experiment Video
Updated: Feb 23, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
[Endovascular Revascularization for Diabetic Foot Ulcer - Experience from a Dedicated Clinic]
Sílvia da Silva1, João Vasconcelos2, Miguel Maia2
1Serviço de Cirurgia Geral, Centro Hospitalar do Tâmega e Sousa EPE, Portugal.
Insights
Endovascular revascularization in diabetic patients with critical limb ischemia shows promising results. This treatment achieved high limb salvage rates and ulcer healing, highlighting its importance in managing diabetic foot disease.
Area of Science:
- Vascular Surgery
- Diabetic Foot Management
- Endovascular Interventions
Context:
- Diabetic patients with chronic limb ischemia often present with severe foot complications.
- Fontaine stage IV ischemia indicates a critical need for revascularization to prevent amputation.
Purpose:
- To evaluate the outcomes of endovascular revascularization in diabetic patients with Fontaine stage IV chronic limb ischemia.
- Primary outcomes assessed included ulcer healing, major amputation rates, and limb salvage.
Summary:
- A retrospective analysis of 106 limbs in 93 diabetic patients undergoing endovascular revascularization was conducted.
- Technical success was 77.4%, with ulcer healing in 53.8% and a limb salvage rate of 90.4% at 24 months.
- Chronic pulmonary disease, nephropathy, and insulin-treated diabetes were associated with poorer outcomes.
Impact:
- Endovascular revascularization is effective in limb salvage for diabetic patients with critical limb ischemia.
- Multidisciplinary care and timely revascularization are crucial for successful diabetic foot disease management.
Objectives:
We aimed to assess the outcome of endovascular revascularization in Diabetic patients with Fontaine stage IV chronic ischaemia, at our Diabetic Foot Clinic. Primary outcomes were ulcer healing, major amputation and limb salvage.
Methods:
Retrospective single center analysis of patients treated between January 2009 and May 2015. Time-dependent event rates were estimated by the Kaplan-Meier method. The differences between groups were evaluated with the chi-square test. A P value below 0,05 was considered statistically significant.
Results:
There were 106 limbs (93 patients) revascularized during the study. The average age was 71 years, and PEDIS 3 or 4 infection was present in 45.3% on admission. 56.6% were treated for femoropopliteal injurie only, 17% infrapopliteal, and 26.4% for both levels. Technical success was achieved in 77.4%, and haemodynamic success in 58.3%. Ulcer healing was attained in 53.8%, with an average healing time of 8.4 months. The major amputation rate was 7.5%, with a limb salvage rate of 90.4% at 6, 12 and 24 months. Chronic pulmo- nary disease decreased the likelihood of healing (p=0,012). Restenosis was more likely to occur in patients with nephropathy (p=0,008) or insulin-treated diabetes (p=0,033).
Conclusions:
Dedicated multidisciplinary teams are key to successful treatment in diabetic foot disease. The good results achieved in our series arise from best medical treatment combined with timely revascularization in those ischemic.
More Related Videos
13:48Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
Published on: April 21, 2023
08:16High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Related Concept Videos
Peripheral Artery Disease V: Postoperative Nursing Management
Peripheral Artery Disease III: Interprofessional Care
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease IV: Nursing Management
Venous Thrombosis III: Interprofessional Care