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Hemorheological dysfunction in cardiac syndrome X.

Emine Kilic-Toprak¹, Olga Yaylali², Yalin Tolga Yaylali³

¹a Faculty of Medicine, Department of Physiology , Pamukkale University , Kinikli , Denizli, Turkey.

Acta Cardiologica

|September 12, 2017

Summary

This summary is machine-generated.

Cardiac Syndrome X (CSX) patients exhibit impaired blood flow properties. This study found reduced erythrocyte deformability and increased erythrocyte aggregation and plasma viscosity in CSX patients, suggesting hemorheological factors contribute to the condition.

Keywords:

Erythrocyte aggregation cardiac syndrome X microvascular angina plasma viscosity red blood cell deformability

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Area of Science:

Cardiology
Hematology
Biophysics

Background:

Cardiac Syndrome X (CSX) presents as angina with normal coronary arteries, but its underlying causes remain unclear.
Investigating blood rheology, including erythrocyte aggregation, deformability, and plasma viscosity, is crucial for understanding CSX pathophysiology.

Purpose of the Study:

To investigate alterations in blood rheology in patients diagnosed with Cardiac Syndrome X.
To determine the relationship between hemorheological parameters and the risk of developing CSX.

Main Methods:

Compared blood rheology (erythrocyte aggregation, deformability, plasma viscosity) in 26 CSX patients and 37 healthy controls.
Utilized ektacytometry for erythrocyte measurements and rotational viscometry for plasma viscosity.

Main Results:

CSX patients showed significantly lower erythrocyte deformability at 1.69 and 3.00 Pa.
Erythrocyte aggregation index and plasma viscosity were significantly higher in CSX patients.
Increased erythrocyte aggregation and RDW, and decreased erythrocyte deformability were associated with CSX risk.

Conclusions:

Hemorheological impairments, including altered erythrocyte aggregation and deformability, are significantly associated with Cardiac Syndrome X.
These findings highlight the role of blood rheology in the pathophysiology of CSX.