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Updated: Feb 23, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Emerging immunotherapy in advanced renal cell carcinoma
Prateek Mendiratta1, Brian I Rini1, Moshe C Ornstein1
1Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.
Immunotherapy shows promise for advanced renal cell carcinoma (RCC). While treatments like nivolumab improve survival, advanced RCC remains largely incurable, necessitating further research into novel immunotherapies.
Area of Science:
- Oncology
- Immunology
Background:
- Renal cell carcinoma (RCC) possesses inherent immunogenic properties, making it a candidate for immunotherapy.
- High-dose interleukin 2 was a historical immunotherapy for advanced RCC (aRCC).
Purpose of the Study:
- To review the current landscape of immunotherapy in advanced RCC.
- To explore future developments in aRCC immunotherapy.
Main Methods:
- Literature review of immunotherapy in advanced RCC.
- Analysis of molecular and immunological alterations in RCC.
Main Results:
- Nivolumab, an anti-PD-1 inhibitor, is FDA-approved for previously treated aRCC, demonstrating improved overall survival.
- Despite advances, aRCC remains largely incurable for most patients.
Conclusions:
- Immunotherapy is a rapidly advancing field for aRCC treatment.
- Further research is crucial to overcome challenges and improve outcomes in aRCC.
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