Related Experiment Video
Updated: Feb 23, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking
Published on: January 28, 2019
The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis
Mark J Wall1, Sonia A L Corrêa2
1School of Life Sciences, University of Warwick, United Kingdom.
Abstract:
The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.
More Related Videos
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
IP3/DAG Signaling Pathway
GPCR Desensitization
Receptor-mediated Endocytosis
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis
Amplifying Signals via Enzymatic Cascade

