How to personalize ovarian stimulation in clinical practice

Area of Science:

• Reproductive Endocrinology
• In Vitro Fertilization (IVF)

Background:

• Controlled ovarian stimulation (COS) is crucial for IVF success.
• Personalizing COS protocols requires accurate prediction of ovarian response.
• Ovarian reserve markers are key to predicting response.

Purpose of the Study:

• To review the ability of ovarian reserve markers to predict poor and high ovarian response in assisted reproductive technology (ART) cycles.
• To discuss how to select optimal COS therapy based on ovarian reserve markers.
• To enhance IVF success rates through individualized stimulation protocols.

Main Methods:

• Literature search for studies on ovarian reserve markers and ART outcomes.
• Analysis of Anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) as predictors.
• Review of different COS protocols and their individualization.

Main Results:

• AMH and AFC are reliable markers for predicting ovarian response (poor, normal, high).
• Predicted response allows for tailored COS protocols (e.g., GnRH-agonists/antagonists, FSH dose).
• Individualized protocols can reduce cycle cancellation and ovarian hyperstimulation syndrome (OHSS) risk.

Conclusions:

• Ovarian reserve markers are essential for predicting IVF outcomes.
• Personalized COS based on these markers improves treatment efficacy and safety.
• Choosing the right COS therapy enhances the chances of successful IVF.