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Flow Cytometric Immune Profiling in Infliximab-Associated Tuberculosis.
Kelly Pennington1, Humberto C Sasieta1, Guiherme P Ramos2
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Clinical Medicine Insights. Case Reports
|September 12, 2017
Summary
Tumor necrosis factor α antagonists increase tuberculosis risk. Flow cytometric immune profiling showed positive results for tuberculosis infection in a patient on infliximab, suggesting it may aid diagnosis in these challenging cases.
Area of Science:
- Immunology
- Infectious Diseases
- Gastroenterology
Background:
- Tumor necrosis factor α (TNF-α) antagonists are widely used for inflammatory and autoimmune conditions.
- Patients on TNF-α antagonists have an increased risk of developing active tuberculosis (TB).
- Diagnosing TB in these patients is difficult due to atypical presentations and potential false-negative diagnostic tests.
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