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Selective immunodeficiency affecting staphylococcal response.

M Monteil1, J Hobbs, K Citron

  • 1Department of Chemical Immunology, Charing Cross and Westminster Medical School, London.

Lancet (London, England)
|October 17, 1987
PubMed
Summary
This summary is machine-generated.

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Patients with recurrent staphylococcal infections showed impaired antibody response, even with normal immunoglobulin levels. Treatment with normal plasma or immunoglobulin therapy improved outcomes, highlighting a specific immune deficiency.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Genetics

Background:

  • Recurrent staphylococcal infections pose significant health challenges.
  • Standard immunological tests, including serum IgG and IgG2, may not identify the underlying cause.
  • Some patients experience severe, life-threatening infections despite normal immunoglobulin levels.

Purpose of the Study:

  • To investigate the immunological basis of recurrent staphylococcal infections in patients with normal IgG and IgG2 levels.
  • To evaluate the efficacy of plasma or immunoglobulin therapy in managing these infections.

Main Methods:

  • Patients underwent standard immunological investigations.
  • A staphylococcal inhibition test was performed.
  • Treatment involved compatible normal plasma or normal immunoglobulin (IgG) therapy.

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  • Treatment duration varied from 6 months to 21 years.

    • Main Results:

    • All patients exhibited persistently subnormal results in the staphylococcal inhibition test.
    • These subnormal results were corrected by plasma or IgG therapy.
    • One patient died from staphylococcal septicaemia after treatment withdrawal.
    • The immune impairment was likely congenital (in utero or inherited) in six patients and acquired later in life in two.

    Conclusions:

    • A specific impairment in anti-staphylococcal antibody response, leading to inadequate antibody production, underlies recurrent staphylococcal infections in these patients.
    • This condition can be congenital or acquired.
    • Immunoglobulin therapy is effective in managing this immune deficiency and preventing severe staphylococcal disease.