Related Experiment Video

Updated: Feb 23, 2026

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.6K

Cardiac troponin and outcome in decompensated heart failure with preserved ejection fraction

Mohammad Thawabi1, Amer Hawatmeh1, Sarah Studyvin1

  • 1Department of cardiology, Newark Beth Israel Medical Center, Newark, New Jersey, USA.

Cardiovascular Diagnosis and Therapy
|September 12, 2017
PubMed

Insights

Elevated cardiac troponin I levels in hospitalized heart failure with preserved ejection fraction patients indicate a higher risk of mortality. This finding highlights troponin

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Cardiac troponin (cTn) is a known prognostic marker in heart failure with reduced ejection fraction.
  • The prognostic significance of cTn in heart failure with preserved ejection fraction (HFpEF) remains unclear.
  • This study investigates the role of troponin I in hospitalized HFpEF decompensation.

Purpose of the Study:

  • To determine the prognostic value of troponin I in patients hospitalized for HFpEF decompensation.
  • To compare mortality rates between HFpEF patients with and without elevated troponin I levels.

Main Methods:

  • Included 363 consecutive patients hospitalized for HFpEF decompensation without acute coronary syndrome.
  • Compared outcomes between patients with elevated troponin I (≥0.04 ng/mL) and normal troponin I levels.
  • Primary outcome: all-cause mortality at short, intermediate, and long-term follow-up.

Main Results:

  • Nearly half of the HFpEF cohort had elevated troponin I levels.
  • Elevated troponin I was significantly associated with increased 30-day, 1-year, and 2-year mortality.
  • Elevated troponin I independently predicted mortality in HFpEF decompensation.

Conclusions:

  • Elevated troponin I levels are associated with significantly higher mortality in hospitalized HFpEF patients.
  • Troponin I elevation serves as a crucial prognostic indicator in HFpEF decompensation.
Abstract

Keywords:
Troponindiastolic heart failure (HF)heart failure with preserved ejection fraction (HFpEF)

More Related Videos

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.8K
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

12.1K

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
969
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
316
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
392
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
634
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.1K