Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fasting requires Peroxiredoxin 2 and Peroxiredoxin 6 to coordinate redox dependent mitochondrial and lipid remodelling in Caenorhabditis elegans.

Redox biology·2026

Same author

Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.

Nature communications·2026

Same author

When complexity does not pay: benchmarking deep learning and ensemble methods for biomarker discovery.

Briefings in bioinformatics·2026

Same author

Early life nutrition and redox dysregulation: Implications for lifelong metabolic health.

Free radical biology & medicine·2026

Same author

Experimental Study on Mechanical Properties and Mix Design Optimization of Nano-SiO<sub>2</sub>-Double-Doped Fiber High-Strength Concrete.

Materials (Basel, Switzerland)·2026

Same author

Poxvirus A52 protein subverts autophagy flux by blocking autophagosome-lysosome fusion to promote viral replication.

PLoS pathogens·2026

Search research articles

Related Experiment Video

Updated: Feb 23, 2026

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

MicroRNA Profiling in Cartilage Ageing.

Panagiotis Balaskas¹, Katarzyna Goljanek-Whysall¹, Peter Clegg¹

¹Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.

International Journal of Genomics

|September 12, 2017

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in aging and disease. This study identified specific miRNAs, including miR-126, that change with cartilage aging and osteoarthritis, offering potential biomarkers and therapeutic targets.

More Related Videos

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Related Experiment Videos

Last Updated: Feb 23, 2026

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Area of Science:

Molecular Biology
Gerontology
Rheumatology

Background:

Osteoarthritis (OA) is a prevalent age-related joint disorder.
MicroRNAs (miRNAs) are small noncoding RNAs involved in cellular regulation, disease, and aging.
Limited research exists on age-related miRNA changes specifically within cartilage.

Purpose of the Study:

To investigate age-related changes in miRNA expression in human cartilage.
To identify potential miRNA biomarkers and therapeutic targets for osteoarthritis and cartilage aging.

Main Methods:

Microarray analysis of young versus old human cartilage samples.
Validation of findings in an independent cohort.
Clustering of differentially expressed miRNAs based on OA severity.

Main Results:

Twenty differentially expressed miRNAs were identified in older human cartilage from an OA environment.
Recognized and novel miRNAs associated with cartilage aging and OA were discovered.
miR-126 was identified as a potential new candidate involved in OA pathogenesis.

Conclusions:

Age-related changes in cartilage miRNA expression are significant in osteoarthritis.
Identified miRNAs, including miR-126, show potential as biomarkers for cartilage aging and OA.
These miRNAs represent promising therapeutic targets for managing osteoarthritis and cartilage aging.