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Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
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Other Helicobacters, gastric and gut microbiota
Christelle Péré-Védrenne1,2, Bram Flahou3, Mun Fai Loke4
1INSERM, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, Bordeaux, France.
Helicobacter
|September 12, 2017
Summary
This review covers recent research on non-Helicobacter pylori infections and H. pylori interactions with the microbiome. New Helicobacter species were found, and probiotic potential was confirmed for preventing infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Gastroenterology
Background:
- Recent literature (2016-2017) on non-Helicobacter pylori infections in humans and animals.
- Focus on interactions between Helicobacter pylori and the stomach/gut microbiota.
- Identification of novel Helicobacter species in various animal hosts.
Purpose of the Study:
- To review key findings on non-H. pylori Helicobacter infections.
- To explore H. pylori interactions with host microbiomes.
- To summarize advancements in infection prevention strategies.
Main Methods:
- Literature review of publications from 2016-2017.
- Analysis of studies on Helicobacter species in humans and animals.
- Examination of research on H. pylori-microbiome interactions.
Main Results:
- New Helicobacter species identified in sea otters, wild boars, dogs, and mice.
- Increased reports of Helicobacter fennelliae and Helicobacter cinaedi in humans, particularly immunocompromised individuals.
- Demonstrated interactions between H. pylori and microbiome beyond the stomach.
Conclusions:
- Mouse models are valuable for studying human Helicobacter infections.
- Understanding of gastric and gut microbiomes has advanced.
- Probiotic properties of Saccharomyces, Lactobacillus, and Bifidobacterium spp. show promise for Helicobacter infection prevention.
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