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Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina

Zeyuan Fan1, Hanhua Ji1, Yang Li1

  • 1Department of Cardiovascular Diseases, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, Beijing, China.

Biomarkers in Medicine
|September 12, 2017
PubMed
Abstract

Insights

The monocyte-to-lymphocyte ratio (MLR) can identify vulnerable plaques in patients with stable angina. Higher MLR levels are linked to thin cap fibrous atheroma and increased necrotic core content.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Medical Imaging

Background:

  • Vulnerable plaques are a key factor in acute coronary syndromes.
  • Accurate identification of vulnerable plaques is crucial for risk stratification in stable angina.

Purpose of the Study:

  • To explore the association between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability.
  • To assess MLR's utility in identifying thin cap fibrous atheroma using virtual histology intravascular ultrasound (VH-IVUS).

Main Methods:

  • 133 patients diagnosed with stable angina were included in this study.
  • Virtual histology intravascular ultrasound (VH-IVUS) was employed to assess plaque characteristics.
  • Monocyte-to-lymphocyte ratio (MLR) was calculated from blood samples.

Main Results:

  • MLR was identified as an independent risk factor for thin cap fibrous atheroma (OR: 2.61; p=0.025).
  • MLR demonstrated a sensitivity of 73.7% and specificity of 61.8% in differentiating thin cap fibrous atheroma.
  • MLR levels positively correlated with the percentage of necrotic core (NC) area and volume.

Conclusions:

  • Circulating MLR levels show potential as a biomarker for identifying vulnerable plaques in stable angina patients.
  • MLR may aid in risk stratification and management of patients with coronary artery disease.
Keywords:
monocyte-to-lymphocyte rationecrotic coreplaque vulnerabilitystable anginathin cap fibrous atheroma

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