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Published on: March 21, 2015
Effect of Conventional and LED Phototherapy on the Antioxidant-Oxidant Status in Preterm Neonates with Jaundice
Anusha Allam1, S R Ravikiran, B Shantaram Baliga
1Departments of Pediatrics and *Community Medicine, Kasturba Medical College, Mangalore, Manipal University, Karnataka, India. Correspondence to: Dr SR Ravikiran, Associate Professor, Department of Pediatrics, Kasturba Medical College, Attavar KMC Hospital, Mangalore, Karnataka, India. ravisaralaya@gmail.com.
Objective:
To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates.
Methods:
Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed.
Results:
Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P<0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P<0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P<0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] µmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P<0.001] in conventional as compared to LED phototherapy.
Conclusion:
Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.
