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Published on: March 26, 2019
Encephalopathy in Henoch-Schönlein Purpura
Huijun Shen1, Jianhua Mao, Qiang Shu
1Departments of Nephrology, *Thoracic and Cardiovascular Surgery, and #Neonatology; The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China. Correspondence to: Dr JH Mao, Department of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China. maojh88@126.com.
Insights
Henoch-Schönlein purpura (HSP), a common childhood vasculitis, can rarely affect the central nervous system (CNS), causing seizures and dysfunction. Aggressive treatment may be needed for prolonged CNS involvement in HSP.
Area of Science:
- Pediatric Rheumatology
- Pediatric Neurology
- Pediatric Vasculitis
Background:
- Henoch-Schönlein purpura (HSP) is the most frequent vasculitis observed in pediatric populations.
- Severe central nervous system (CNS) involvement is an uncommon manifestation of HSP.
Background:
Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. Severe central nervous system (CNS) involvement is rare in HSP.
Case Characteristics:
Three children with features of HSP presented with seizures and CNS dysfunction.
Observation:
All three children had abnormalities on neuroimaging; 2 had complete remission but one was left with severe neurological damage.
Message:
HSP patients may rarely present with CNS involvement with a prolonged course requiring aggressive treatment.
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