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Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...

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Related Experiment Video

Updated: Feb 23, 2026

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Concurrent Recording of Co-localized Electroencephalography and Local Field Potential in Rodent

Published on: November 30, 2017

Extrapolating meaning from local field potential recordings.

Amber L Harris Bozer¹, Megan L Uhelski², Ai-Ling Li³

¹Department of Psychological Sciences, Tarleton State University, Stephenville, Texas 76402, USA.

Journal of Integrative Neuroscience

|September 12, 2017

Summary

Local field potential (LFP) recording offers insights into cellular activity near electrodes. This review covers LFP basics, techniques, analysis, and clinical uses for researchers new to LFP.

Keywords:

LFP electrophysiology extracellular field potentials local field potentials

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Published on: June 22, 2017

Area of Science:

Neuroscience
Electrophysiology

Background:

Local field potentials (LFP) represent low-frequency neural activity near recording electrodes.
LFP recording provides a valuable window into diverse cellular activities.
Interest in LFP research has grown significantly in recent years.

Purpose of the Study:

To provide a comprehensive resource for researchers new to LFP.
To clarify conceptual issues surrounding LFP recording and analysis.
To guide non-experts in implementing LFP techniques.

Main Methods:

Review of major conceptual issues in LFP.
Discussion of cellular origins of LFP signals.
Examination of LFP recording techniques, including recommendations and limitations.
Exploration of LFP data analysis methods, emphasizing power-band analyses.
Overview of clinical applications of LFP.

Main Results:

Detailed explanation of the cellular basis of LFP.
Practical guidance on LFP recording methodologies.
Introduction to common LFP data analysis strategies.
Summary of successful clinical implementations of LFP.

Conclusions:

LFP is a versatile tool for studying neural activity.
This review serves as a foundational guide for LFP implementation.
Understanding LFP principles is crucial for its effective application in research and clinics.