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Updated: Feb 23, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
Published on: June 2, 2020
Extracellular matrix and its role in conveying glial/neural interactions in health and disease
Vera Maura Fernandes de Lima1,2, Wolfgang Hanke3
1Centro de Biotecnologia, CNEN-IPEN/SP, Av. Lineu Prestes 2242, Campus USP, São Paulo, SP, Brazil, 05508-000.
Abstract:
We review the concepts and findings that may be related to the occurrence of non-linear glial/neural dynamics involving interactions between polyelectrolytes of the extracellular matrix and the basement membranes that cover the endfeet of glia at CNS interfaces. Distortions of perception and blocking of learning expressed in functional syndromes are interpreted as macroscopic electrochemical patterns that emerge in grey matter through glial/neural interactions.
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