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Nonsynaptic plasticity model of long-term memory engrams.

L A Cacha1, J Ali1,2, Z H Rizvi1

  • 1Laser Centre, Ibnu Sina ISIR, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.

Journal of Integrative Neuroscience
|September 12, 2017
PubMed
Summary
This summary is machine-generated.

This study proposes that stable electrical pulses in non-ohmic dendrites represent enduring memories. These memories are encoded via epigenetic mechanisms and nonsynaptic plasticity, offering insights into memory storage and retrieval.

Keywords:
Cable theorycharged proteinselectrotonic processingepigenetic mechanismsmemory engramnonsynaptic diffusion neurotransmissionnonsynaptic plasticitysignaling cascades

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Understanding the biophysical mechanisms of memory storage is crucial.
  • Existing models often focus on synaptic plasticity, neglecting other potential mechanisms.
  • Non-ohmic dendritic properties offer a novel perspective on neural computation.

Purpose of the Study:

  • To investigate the role of electrotonic potentials in non-ohmic dendrites as potential electrical signatures of enduring memories.
  • To propose a theoretical framework for how these stationary pulses are formed, encoded, and retrieved.
  • To link nonsynaptic plasticity and epigenetic mechanisms to memory formation and recall.

Main Methods:

  • Application of cable theory to model steady-state electrical properties of non-ohmic dendrites.
  • Derivation of localized, time-independent electrotonic potentials (standing pulses).
  • Hypothetical modeling of memory encoding, retrieval, and reconsolidation processes.

Main Results:

  • Identification of stationary, localized electrotonic potentials in non-ohmic dendrites.
  • Hypothesized these pulses as electrical signatures of enduring memories.
  • Proposed a mechanism for memory retrieval involving integration of these pulses via extracellular neurotransmission.

Conclusions:

  • Electrotonic processing in non-ohmic dendrites provides a plausible mechanism for permanent memory engrams.
  • Nonsynaptic plasticity and epigenetic mechanisms are implicated in memory encoding and retrieval.
  • Standing electrotonic pulses may represent a fundamental unit of enduring memory storage.