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Related Experiment Video

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[Bioactive lignans from Silybum marianum].

Yan Zhang1, Yu-Bo Peng1, Xiao-Zhong Chen1

  • 1Jiamusi college of Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 12, 2017
PubMed
Summary

Seven novel compounds were isolated from Silybum marianum seeds. Four compounds showed activity against influenza A (H5N1), and four compounds exhibited cytotoxicity against HepG-2 cells.

Keywords:
Silybum marianumanti-influenza virus activitycytotoxitylignan

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacology

Background:

  • Silybum marianum (milk thistle) seeds are a rich source of bioactive compounds.
  • Previous research has explored various extracts, but novel compound isolation remains an active area.

Purpose of the Study:

  • To isolate and identify novel chemical constituents from Silybum marianum seeds.
  • To evaluate the antiviral activity of isolated compounds against influenza A (H5N1).
  • To assess the cytotoxic effects of isolated compounds on HepG-2 cells.

Main Methods:

  • Hot water extraction of Silybum marianum seeds.
  • Isolation and purification using D101 macroporous resin, MCI resin, MPLC, and HPLC.
  • Chemical structure elucidation using spectroscopic methods.
  • In vitro antiviral and cytotoxic assays.

Main Results:

  • Seven compounds were isolated and identified for the first time: tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (1), tricin 4'-O-[erythro-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (2), 5'-methoxyhydnocarpin-D (3), palstatin (4), (8R,7'S,8'R)-5,5'-dimethoxy-7-oxolariciresinol 9'-O-D-xylopyranoside (5), 9-O-D-glucopyranoside (6), and (-)-haplomyrtoside (7).
  • Compounds 1, 3, 4, and 5 demonstrated activity against influenza A (H5N1) with IC₅₀ values ranging from 0.21 to 0.65 μmol•L⁻¹.
  • Compounds 1, 2, 6, and 7 exhibited cytotoxicity against HepG-2 cells with IC₅₀ values ranging from 0.25 to 0.66 μmol•L⁻¹.

Conclusions:

  • The study successfully identified seven novel compounds from Silybum marianum seeds.
  • The isolated compounds show potential as antiviral agents against influenza A (H5N1) and possess cytotoxic properties against HepG-2 cells, warranting further investigation.