[Chrononephrotoxicity of amikacin after 7-day chronic poisoning in rats]

We have studied the chrononephrotoxicity of amikacin during and after a prolonged treatment in rats. Animals received by intramuscular route a daily dose of 400 mg/kg during 7 days at four different times (08:00, 14:00, 20:00 or 02:00). Large time-dependent variations in renal injury had been evidenced by several parameters and particularly by enzymuria. This injury is maximal when administration is made at 14:00. These data confirmed results obtained in previous investigations. The knowledge of chrononephrotoxicity could permit an optimization of drugs in clinics.