[Hypogonadotropic hypogonadism combined with anosmia (Kallmann's syndrome)]

Diagnosis in Kallmann's syndrome is often erroneous and results in the administration of inadequate therapy. The aim of the study was to define characteristic features of a course of disease and to administer adequate therapy. It has been established that cases of Kallmann's syndrome are rather frequent. Patients with hypogonadism should be examined with respect to anosmia because such a combination suggests the diagnosis of Kallmann's syndrome. The selection of a therapeutic method should be strictly individual bearing in mind a degree of hypoplasia and the presence of cryptorchism. In the combination of Kallmann's syndrome with cryptorchism CG therapy results in the elimination of cryptorchism without surgery in most patients. Chorionic gonadotropin should be administered in combination with androgens in marked testicular hypoplasia in any period at the reproductive age; later on it can be only chorionic gonadotropin. Correct diagnosis and adequate therapy lead to sex and social rehabilitation of patients with Kallmann's syndrome decreasing the number of sterile men.