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Electrochemical immunoassays.

M J Green1

  • 1Genetics International, Abingdon, Oxfordshire, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 28, 1987
PubMed
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Electrochemical immunoassays offer sensitive detection of antigens without radioactive labels. Enzyme labels coupled with electrochemical detection methods are particularly effective for detecting drugs like lidocaine.

Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Immunotechnology

Background:

  • Immunoassays are vital for detecting low antigen levels.
  • Radioisotopic labels are being replaced by alternative labels with electrochemical activity.
  • Enzyme labels with amperometric or potentiometric detection are successful immunoassay strategies.

Purpose of the Study:

  • To explore electrochemical immunoassay development beyond spectrophotometric adaptations.
  • To highlight potentiometric immunoassays measuring antibody-antigen binding-induced potential changes.
  • To discuss the advantages of enzyme-linked assays for drug detection, specifically lidocaine.

Main Methods:

  • Development of electrochemical immunoassays.
  • Utilizing enzyme labels with amperometric or potentiometric detection.

Related Experiment Videos

  • Designing assays based on electrochemical principles.

    • Main Results:

    • Proliferation of alternative labels with electrochemical activity.
    • Successful implementation of enzyme labels with electrochemical detection.
    • Development of potentiometric immunoassays for antigen detection.
    • Electroactive labels enable drug immunoassays.

    Conclusions:

    • Electrochemical immunoassays provide sensitive alternatives to radioisotopic methods.
    • Enzyme-linked assays are advantageous for detecting specific drugs like lidocaine.
    • Potentiometric detection offers a direct measure of antibody-antigen interactions.