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Biosensors in process control.

D J Clarke1

  • 1Sensor Group, PHLS Centre for Applied Microbiology and Research, Salisbury, Wiltshire, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 28, 1987
PubMed
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Developing advanced biosensors and physical measurement techniques is crucial for enhanced bioprocess control. These innovations will monitor cell growth and downstream parameters for improved efficiency.

Area of Science:

  • Biotechnology and Bioprocess Engineering
  • Analytical Chemistry
  • Biosensor Technology

Background:

  • Effective bioprocess control necessitates comprehensive monitoring of cell growth and downstream parameters.
  • Current monitoring methods may lack the specificity or real-time capabilities required for advanced control strategies.

Purpose of the Study:

  • To explore the development and application of biosensor devices and physical measurement techniques for improved bioprocess monitoring.
  • To identify key parameters for cell growth and downstream processing that require novel monitoring solutions.

Main Methods:

  • Review and discussion of acoustic, dielectric, and laser light scattering techniques for biomass parameter analysis.
  • Examination of biosensor developments, including membrane sampling-flow analysis probes and direct biosensing principles.

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Main Results:

  • Acoustic, dielectric, and laser light scattering show promise as analytical tools for biomass parameters.
  • Biosensor applications in flow analysis probes and direct sensing principles offer potential for real-time monitoring.

Conclusions:

  • Advancements in biosensors and physical measurement techniques are essential for sophisticated bioprocess control.
  • Further development in these areas will enable more precise monitoring of critical bioprocess parameters.