Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.2K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.2K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteolytic EphA2 fragments cooperatively promote hepatocellular carcinoma progression.

Cell death & disease·2026
Same author

Evaluation of variations in urine laminin-γ2 monomer in non-muscle-invasive bladder cancer before and after transurethral resection of the bladder tumor.

BMC cancer·2026
Same author

Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.

Nature communications·2025
Same author

Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction.

Life science alliance·2025
Same author

Biomechanical control of vascular morphogenesis by the surrounding stiffness.

Nature communications·2025
Same author

Laminin-γ2-NR6A1 Fusion Protein Promotes Metastatic Potential in Non-Small-Cell Lung Carcinoma Cells without Epidermal Growth Factor Receptor Mutation.

The American journal of pathology·2025

Related Experiment Video

Updated: Feb 23, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.1K

Study on the tumor-induced angiogenesis using mathematical models.

Takashi Suzuki1, Dhisa Minerva1, Koichi Nishiyama2

  • 1Center for Mathematical Modeling and Data Science, Osaka University, Osaka, Japan.

Cancer Science
|September 12, 2017
PubMed
Summary

This study uses mathematical models to simulate angiogenesis, focusing on tip cell dynamics and extracellular matrix degradation. New numerical simulation techniques generate realistic images of blood vessel growth.

Keywords:
angiogenesisextracellular matrix degradationhybrid simulationmathematical modeltumor microenvironment

More Related Videos

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

13.1K
Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

2.4K

Related Experiment Videos

Last Updated: Feb 23, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.1K
The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

13.1K
Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
07:26

Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

Published on: September 15, 2023

2.4K

Area of Science:

  • Biophysics
  • Mathematical Biology
  • Computational Biology

Background:

  • Angiogenesis is a crucial biological process involving new blood vessel formation.
  • Mathematical models are essential for understanding the complex dynamics of angiogenesis.
  • Tip cells play a pivotal role in guiding blood vessel sprouting.

Purpose of the Study:

  • To investigate angiogenesis using mathematical models of tip cell dynamics.
  • To review existing angiogenesis models and numerical simulation techniques.
  • To generate realistic computer graphics of sprouting angiogenesis.

Main Methods:

  • Examined the Anderson-Chaplain model incorporating mass transport, chemical reactions, and ECM degradation.
  • Developed model-faithful and model-driven numerical schemes.
  • Introduced novel simulation techniques: transient probability, particle velocity, and Boolean variables.

Main Results:

  • Successfully simulated sprouting angiogenesis using mathematical modeling.
  • Generated realistic computer graphics of the angiogenesis process.
  • Validated new numerical simulation techniques for biological processes.

Conclusions:

  • Mathematical modeling provides a powerful tool for studying angiogenesis.
  • Advanced numerical schemes enhance the accuracy and realism of angiogenesis simulations.
  • This work contributes to a better understanding of blood vessel formation.