Related Experiment Video
Updated: Feb 23, 2026
09:31
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
11.1K
Primary Amyloidosis - In a Case with Normal Plasma Cell Counts
Pooja Trehan1, Mangala Gouri2, Clement Wilfred3
1Postgraduate Student, Department of Pathology, MS Ramaiah Medical College, Bengaluru, Karnataka, India.
Journal of Clinical and Diagnostic Research : JCDR
|September 13, 2017
Summary
Amyloidosis diagnosis can be challenging due to nonspecific imaging findings. This case highlights the rare detection of amyloid deposits in bone marrow aspiration, emphasizing the need for biopsy confirmation.
Area of Science:
- Medicine
- Pathology
- Radiology
Background:
- Amyloidosis involves extracellular deposition of abnormal proteinaceous material (amyloid) in organs.
- Liver involvement is common, but radiological findings are often nonspecific.
- Diagnosis can be difficult due to non-specific clinical and imaging presentations.
Related Concept Videos
03:03Amyloid Fibrils
12.1K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
12.1K
03:03Amyloid Fibrils
6.8K
6.8K
01:27Disorders of Leukocytes
2.1K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.1K