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Secondary Lymphoid Organs

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The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Double-locus lymphoplasmacytic aortitis.

Szabolcs Miskolczi¹, Mary N Sheppard², Gábor Bogáts³

¹1 Department Cardiothoracic Surgery, 7425 Southampton General Hospital , Southampton, UK.

Asian Cardiovascular & Thoracic Annals

|September 13, 2017

Summary

This summary is machine-generated.

Immunoglobulin G4-related aortitis is a rare condition affecting the aorta. This case highlights a double-locus presentation, emphasizing the need for comprehensive evaluation in thoracic aortic aneurysm cases.

Keywords:

Aortic aneurysm Aortitis Immunoglobulin G4 Intramural hematoma Plasma cells Thoracic

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Area of Science:

Cardiovascular Medicine
Immunology
Pathology

Background:

Thoracic aortic aneurysms often stem from hypertension and atherosclerosis, potentially leading to acute aortic syndrome.
Immunoglobulin G4-related aortitis is an uncommon condition involving lymphoplasmacytic infiltration of the aortic wall.
Its histological resemblance to other immunoglobulin G4-related diseases suggests a potential systemic origin.

Observation:

A 72-year-old male patient presented with an incidental finding of intramural hematoma.
The finding was discovered during a thoracic computed tomography scan for respiratory evaluation.
The patient was diagnosed with double-locus lymphoplasmacytic aortitis.

Findings:

The aortitis exhibited lymphoplasmacytic induration of the vascular tunica media.
No clear infectious or systemic autoimmune causes were identified.
Histological features suggested a potential link to systemic Immunoglobulin G4-related disease.

Implications:

This case highlights a rare manifestation of Immunoglobulin G4-related disease.
It underscores the importance of considering systemic conditions in aortitis diagnosis.
Further research may elucidate the systemic implications of this rare aortitis subtype.