Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

3.5K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.5K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1.5K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

695
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
695
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

476
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
476
Inflammation01:38

Inflammation

62.7K
Overview
62.7K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.3K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Deficiency of the Macrophage Csf2ra Receptor Modulates Inflammatory Responses Following Cardiac Ischaemic Injury in Mice.

Cells·2026
Same author

Suppression of CSF2RA macrophage polarisation impacts pathological cardiac remodelling in mice.

Scientific reports·2026
Same author

Non-culprit plaque healing on serial OCT imaging and future outcome in patients with acute coronary syndromes.

Atherosclerosis·2025
Same author

FGL2/FcγRIIB Signalling Mediates Arterial Shear Stress-Mediated Endothelial Cell Apoptosis: Implications for Coronary Artery Bypass Vein Graft Pathogenesis.

International journal of molecular sciences·2024
Same author

WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing.

Cells·2024
Same author

Pharmacological Inhibition of MMP-12 Exerts Protective Effects on Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice.

International journal of molecular sciences·2024
Same journal

Corrigendum to "Interleukin-4 alleviate polycystic ovary syndrome through promoting the polarization of M2 type macrophages via targeting NF-κB/IκB pathway" [Eur. J. Pharmacol. (2026) 1026 178965].

European journal of pharmacology·2026
Same journal

Hypericin: A potential gut microbiota-based therapeutic for postpartum depression via modulating bile acid metabolism.

European journal of pharmacology·2026
Same journal

Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

European journal of pharmacology·2026
Same journal

Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

European journal of pharmacology·2026
Same journal

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

European journal of pharmacology·2026
Same journal

4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

European journal of pharmacology·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

10.6K

Metalloproteinases in atherosclerosis.

Jason L Johnson1

  • 1Laboratory of Cardiovascular Pathology, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Level 7, Bristol Royal Infirmary, Marlborough Street, BS2 8HW, United Kingdom.

European Journal of Pharmacology
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Matrix metalloproteinases (MMPs) play dual roles in atherosclerosis, influencing plaque stability and rupture. Selective inhibition of specific MMPs may offer new therapeutic strategies to reduce cardiovascular disease.

Keywords:
ADAMADAMTS cellAtherosclerosisMMPMetalloproteinaseProteasesTIMP

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.5K
Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.1K

Related Experiment Videos

Last Updated: Feb 23, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

10.6K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.5K
Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.1K

Area of Science:

  • Cardiovascular Biology
  • Protease Biochemistry

Background:

  • Atherosclerosis is a leading cause of global mortality, driven by cardiovascular diseases.
  • Proteases, particularly matrix metalloproteinases (MMPs), are implicated in vascular extracellular matrix degradation and atherosclerotic plaque development.
  • MMPs and their inhibitors (TIMPs) exhibit complex roles in plaque progression and rupture.

Purpose of the Study:

  • To review evidence linking individual MMPs to atherosclerotic plaque development, progression, and instability.
  • To discuss the diverse functions of MMPs and their implications in atherosclerosis.
  • To highlight the need for selective MMP inhibition and surrogate markers.

Main Methods:

  • Review of existing literature on MMPs in atherosclerosis.
  • Analysis of animal models and human studies.
  • Discussion of MMP structural, functional, and cell-specific diversity.

Main Results:

  • MMPs contribute to both plaque stabilization (promoting smooth muscle cell survival) and rupture (via matrix degradation and inflammation).
  • Evidence from animal models and human studies supports the dual role of MMPs.
  • Selective targeting of individual MMPs is crucial due to their varied functions.

Conclusions:

  • Understanding the complex roles of specific MMPs in plaque progression and rupture is essential.
  • Further clinical trials evaluating selective MMP inhibition are warranted.
  • Targeted MMP inhibition holds potential for reducing cardiovascular morbidity and mortality.