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Published on: March 29, 2022
Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia
Huijuan Guo1, Maja Rischer1, Martin Sperfeld2
1Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraβe 11a, D-07745 Jena, Germany.
Abstract:
Illumina 16S rRNA gene sequencing was used to profile the associated bacterial community of the marine hydroid Hydractinia echinata, a long-standing model system in developmental biology. 56 associated bacteria were isolated and evaluated for their antimicrobial activity. Three strains were selected for further in-depth chemical analysis leading to the identification of 17 natural products. Several γ-Proteobacteria were found to induce settlement of the motile larvae, but only six isolates induced the metamorphosis to the primary polyp stage within 24h. Our study paves the way to better understand how bacterial partners contribute to protection, homeostasis and propagation of the hydroid polyp.
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