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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Epstein-Barr virus-associated lymphomas.

Claire Shannon-Lowe1, Alan B Rickinson1, Andrew I Bell2

  • 1Institute of Immunology and Immunotherapy, The Medical School, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Epstein-Barr virus (EBV) is linked to various lymphomas by affecting B-cells and other cell types. Its role in lymphomagenesis involves complex interactions between viral gene expression and cellular changes in affected individuals.

Keywords:
Burkitt lymphomaEpstein–Barr virusHodgkin lymphomaT/NK lymphomadiffuse large B cell lymphomapost-transplant lymphoproliferative disease

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Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Epstein-Barr virus (EBV) is etiologically linked to a wide spectrum of lymphoproliferative disorders and lymphomas.
  • EBV's association with Burkitt lymphoma is well-established, but its role extends to B-, T-, and NK-cell malignancies.
  • Some EBV-associated lymphomas arise from viral persistence in B-cells, while others result from infection of atypical target cells.

Purpose of the Study:

  • To review recent advancements in understanding EBV-associated lymphomagenesis.
  • To explore the complex interplay of viral and cellular factors in the pathogenesis of EBV-associated lymphomas.
  • To discuss EBV's role in lymphomagenesis in both immunocompetent and immunocompromised hosts.

Main Methods:

  • Review of recent scientific literature on Epstein-Barr virus and lymphomagenesis.
  • Analysis of the interplay between viral gene expression patterns and cellular genetic alterations.
  • Synthesis of findings concerning EBV-associated lymphomas in diverse host populations.

Main Results:

  • EBV is a potent B-cell transforming agent, suggesting a role in lymphomagenesis.
  • The pathogenesis of EBV-associated lymphomas is complex, involving intricate interactions between viral and host cellular factors.
  • EBV contributes to lymphomagenesis through viral persistence and entry into unnatural target cells.

Conclusions:

  • EBV plays a significant role in the development of various lymphomas.
  • Understanding the complex pathogenesis of EBV-associated lymphomas is crucial for both immunocompetent and immunocompromised individuals.
  • Further research into the interplay of viral and cellular factors is essential for targeted therapeutic strategies.