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Updated: Feb 23, 2026
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
4.8K
Viral hepatitis and liver cancer
Marc Ringelhan1,2,3, Jane A McKeating4,5, Ulrike Protzer6,3,7
1Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Muenchen, Germany.
Summary
Hepatitis B and C viruses are leading causes of liver cancer (hepatocellular carcinoma, HCC) globally, responsible for over 1.3 million deaths annually. Understanding viral roles in HCC is crucial for developing new treatments.
Area of Science:
- Hepatology
- Virology
- Oncology
Background:
- Hepatitis B (HBV) and C (HCV) viruses cause significant global health issues, leading to liver cirrhosis and hepatocellular carcinoma (HCC).
- Viral infections are the primary drivers of HCC worldwide, contributing to substantial mortality.
- HCC is the second leading cause of cancer death globally, with HBV and HCV being major etiological factors.
Purpose of the Study:
- To review current knowledge on hepatitis B and C virus-induced liver cancer (hepatocarcinogenesis).
- To elucidate the direct and indirect risk factors contributing to viral-associated HCC.
- To emphasize the importance of understanding viral mechanisms in HCC for future therapeutic strategies.
Main Methods:
- This is a review article, synthesizing existing research.
- Information was gathered from scientific literature on HBV, HCV, and HCC.
- The review focuses on summarizing established knowledge and identifying risk factors.
Main Results:
- Hepatitis B and C viruses are the leading causes of HCC globally.
- These infections account for a significant portion of the 1.3 million annual deaths from liver cancer.
- HBV can promote HCC even without pre-existing liver cirrhosis.
Conclusions:
- Understanding the mechanisms of viral hepatocarcinogenesis is essential for advancing HCC treatment and prevention.
- Identifying direct and indirect risk factors can guide targeted interventions.
- Further research into viral roles in liver cancer is critical for public health outcomes.
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