Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

7.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

49.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.9K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.2K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.6K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro TLR4 Stimulating Bioactivities of Amylase/Trypsin-Inhibitors from Wheat (<i>Triticum aestivum</i> L.) Bred from 1891 to 2010.

Foods (Basel, Switzerland)·2026
Same author

A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs.

mBio·2025
Same author

Collagen XXIII (COL23A1): A novel risk factor for eczema herpeticum.

The Journal of allergy and clinical immunology·2025
Same author

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits.

EBioMedicine·2025
Same author

A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation.

Journal of virology·2024
Same author

Structural changes shaping the Drosophila ellipsoid body ER-neurons during development and aging.

Developmental biology·2024

Related Experiment Video

Updated: Feb 23, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K

Kaposi sarcoma herpesvirus pathogenesis.

Giuseppe Mariggiò1,2, Sandra Koch1,2, Thomas F Schulz3,2

  • 1Institute of Virology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 13, 2017
PubMed
Summary

Kaposi sarcoma herpesvirus (KSHV), or human gammaherpesvirus 8, causes cancers like Kaposi sarcoma. Understanding KSHV pathogenesis and transmission is key to developing new therapies and a potential vaccine.

Keywords:
DNA damage responseKSHVKSHV-related diseasesaberrant angiogenesisinnate immune evasionviral infection

More Related Videos

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
07:10

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

Published on: August 15, 2025

880
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

9.4K

Related Experiment Videos

Last Updated: Feb 23, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

13.1K
Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
07:10

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

Published on: August 15, 2025

880
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

9.4K

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Kaposi sarcoma herpesvirus (KSHV), also known as human gammaherpesvirus 8, is an ancient human virus.
  • KSHV is prevalent in specific global regions and ethnic groups, with seroprevalence exceeding 10% in sub-Saharan Africa.

Purpose of the Study:

  • To review the pathogenesis of KSHV-associated malignancies.
  • To discuss the role of cofactors, such as immune defects and inflammation, in KSHV disease.
  • To explore potential therapeutic strategies and vaccine development for KSHV.

Main Methods:

  • Review of existing literature on KSHV virology, epidemiology, and pathogenesis.
  • Analysis of KSHV's role in human oncogenesis and disease development.
  • Synthesis of current knowledge on KSHV life cycle and disease mechanisms.

Main Results:

  • KSHV is linked to Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.
  • KSHV requires cofactors like immune compromise and inflammation to cause disease.
  • Improved understanding of KSHV pathogenesis offers avenues for targeted therapies.

Conclusions:

  • Targeting key viral proteins or host pathways crucial for KSHV replication is a promising therapeutic strategy.
  • The virus's limited distribution presents an opportunity for vaccine development to prevent transmission.
  • Further research into KSHV pathogenesis can lead to novel treatments and preventative measures.