Related Experiment Video

Updated: Feb 23, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
09:38

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

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Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation

Da-Xiong Zeng1, Chang-Guo Wang1, Jian-An Huang1

  • 1Department of Respiratory and Critical Care, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Oncotargets and Therapy
|September 13, 2017
PubMed

Insights

Apatinib showed potential as a salvage treatment for advanced lung adenocarcinoma with KRAS mutations, offering stable disease in most patients after second-line therapy. This offers a new option for patients with poor prognosis.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Activating KRAS mutations in lung adenocarcinoma are linked to treatment resistance and poor outcomes.
  • Apatinib, a VEGFR-2 inhibitor, has shown efficacy in gastric and breast cancers.

Purpose of the Study:

  • To evaluate apatinib as a salvage treatment for advanced lung adenocarcinoma patients with KRAS mutations.

Main Methods:

  • Four patients with advanced KRAS-mutated lung adenocarcinoma received oral apatinib (250 mg/d) post-second-line treatment.
  • Disease response and progression-free survival (PFS) were monitored.

Main Results:

  • One patient had progressive disease; three achieved stable disease.
  • The median PFS was 3.8 months (range: 1.5-5.5 months).
  • Manageable toxicities included hoarseness and hemoptysis.

Conclusions:

  • Apatinib may serve as a viable salvage treatment option for advanced lung adenocarcinoma patients with KRAS mutations who have progressed after second-line therapy.
Keywords:
KRAS mutationVEGFR-2apatiniblung cancer

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