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Related Experiment Video

Updated: Feb 23, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Behavioral Changes in Patients with Multiple Sclerosis.

Mirjam R Heldner¹, Sigal Kaufmann-Ezra², Klemens Gutbrod²

¹Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Frontiers in Neurology

|September 13, 2017

Summary

This summary is machine-generated.

Behavioral changes are common in multiple sclerosis (MS) patients, affecting up to one-third. These changes correlate with fatigue and depression, not disease severity or disability, and warrant specific testing.

Keywords:

Frontal Systems Behavior Scale behavioral changes cognition disability evaluation multiple sclerosis

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Area of Science:

Neurology
Neuropsychology

Background:

Behavioral changes are frequently observed in multiple sclerosis (MS) patients but often overlooked compared to cognitive deficits.
Recognizing these behavioral alterations is crucial for comprehensive patient care.

Purpose of the Study:

To investigate the prevalence of behavioral changes in MS patients.
To analyze the relationship between behavioral changes and disease characteristics, physical disability, and cognitive impairments in MS.

Main Methods:

A cross-sectional study involving 66 MS patients.
Neuropsychological assessment using the Frontal Systems Behavior Scale (FrSBe), Beck Depression Inventory (BDI), and Wuerzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS).
Correlation analysis of FrSBe scores with clinical and cognitive data.

Main Results:

Approximately one-third of MS patients exhibited behavioral changes.
Behavioral changes were associated with fatigue and depressive symptoms (BDI, WEIMuS).
No significant correlation was found between behavioral changes and disease duration, physical disability (Expanded Disability Status Scale), or cognitive function.

Conclusions:

Behavioral changes are prevalent in MS, even in mildly affected individuals.
These changes are largely independent of disease characteristics and disability but linked to fatigue and depression.
Specific screening for behavioral changes in MS patients is recommended.