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Inhibition of erythrocyte transglutaminase by GTP
C M Bergamini1, M Signorini, L Poltronieri
1Istituto di Chimica Biologica dell'Università, Ferrara, Italy.
Biochimica Et Biophysica Acta
|November 5, 1987
Abstract:
The guanine nucleotides GTP, GDP and GMP inhibit the activity of erythrocyte transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13) in a decreasing order of effectiveness. The inhibition is more apparent at low than at saturating levels of calcium ions and is not due to the chelation of Ca2+, but to an interference with the process of activation by the cation. This inhibition is likely to contribute to the latency of erythrocyte transglutaminase in physiological conditions.