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Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Feb 23, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

Macrophages Generate Pericytes in the Developing Brain.

Pedro H D M Prazeres¹, Viviani M Almeida¹, Luiza Lousado¹

¹Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Cellular and Molecular Neurobiology

|September 13, 2017

Summary

This summary is machine-generated.

Brain pericyte origins are clarified: a subpopulation arises from phagocytic macrophages during development. This discovery offers new insights into neurodevelopmental disorders and potential therapeutic strategies.

Keywords:

Brain Development Origin Pericytes

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Last Updated: Feb 23, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse

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Published on: January 14, 2020

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Culture of Brain Capillary Pericytes for Cytosolic Calcium Measurements and Calcium Imaging Studies

Culture of Brain Capillary Pericytes for Cytosolic Calcium Measurements and Calcium Imaging Studies

Published on: May 27, 2020

Area of Science:

Developmental biology
Neuroscience
Cell biology

Background:

Pericytes are crucial cells ensheathing cerebral blood vessels, but their embryonic origins are not fully understood.
Recent findings reveal pericyte diversity, prompting further investigation into their developmental sources.
Understanding pericyte origins is key to addressing neurodevelopmental disorders.

Purpose of the Study:

To investigate the embryonic origins of diverse brain pericyte subpopulations.
To identify potential precursor cells for cerebral pericytes during vascular development.

Main Methods:

Utilized advanced techniques, including multiple transgenic mouse models.
Employed state-of-the-art methodologies for cell lineage tracing and analysis.

Main Results:

Identified a subpopulation of brain pericytes originating from phagocytic macrophages.
Demonstrated a novel developmental pathway for a subset of cerebral pericytes.
Revealed phagocytic macrophages as a potential precursor for brain pericytes.

Conclusions:

Phagocytic macrophages represent a newly identified source of brain pericytes.
This finding expands our understanding of cerebral vascular development.
The research may pave the way for novel therapeutic approaches for neurodevelopmental disorders.