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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

552
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Feb 23, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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How to optimize the lung donor.

Gabriele Sales1, Andrea Costamagna1, Vito Fanelli1

  • 1Department of Surgical Sciences, University of Turin, Turin, Italy.

Minerva Anestesiologica
|September 13, 2017
PubMed
Summary
This summary is machine-generated.

Lung transplantation is a vital treatment for end-stage lung disease. Strategies like ex-vivo lung perfusion (EVLP) improve donor lung utilization, but further research is needed to optimize EVLP and manage donor lung injuries.

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Area of Science:

  • Cardiovascular and Respiratory System Sciences
  • Transplantation Medicine
  • Organ Preservation

Background:

  • Lung transplantation is the standard of care for advanced lung disease.
  • High waiting list mortality (10% in Italy, 2016) and low transplant rates (39%) highlight donor lung scarcity.
  • Donor lung optimization strategies are crucial to improve outcomes.

Purpose of the Study:

  • To review current strategies for optimizing donor lungs before retrieval.
  • To present the role of ex-vivo lung perfusion (EVLP) in lung transplantation.
  • To discuss ongoing research and challenges in donor lung injury management.

Main Methods:

  • Review of existing literature on donor lung optimization techniques.
  • Analysis of the application and efficacy of ex-vivo lung perfusion (EVLP).
  • Discussion of emerging approaches for managing specific donor lung injuries.

Main Results:

  • Protective ventilation, fluid management, and hormonal therapy can improve donor lung function.
  • EVLP expands the donor pool without compromising other organs or recipient outcomes.
  • Further research is needed on EVLP ventilation strategies, ischemia-reperfusion injury, infection prophylaxis, and targeted therapies.

Conclusions:

  • Optimizing donor lungs and utilizing EVLP are key to increasing lung transplant accessibility.
  • Addressing specific donor lung injuries and refining EVLP protocols are critical for future advancements.
  • Continued investigation into EVLP and donor lung management is essential to improve lung transplant success rates.