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Identification of potential key genes associated with diffuse large B-cell lymphoma based on microarray gene

X Luo, F Shi, H Qiu

    Neoplasma
    |September 13, 2017
    PubMed
    Summary

    This study identified key genes, microRNAs (miRNAs), and transcription factors (TFs) linked to diffuse large B-cell lymphoma (DLBCL). These findings highlight potential therapeutic targets for DLBCL progression.

    Keywords:
    Diffuse large B-cell lymphomadifferentially expressed genemiRNA functional interaction.transcription factor

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    Area of Science:

    • Oncology
    • Genomics
    • Bioinformatics

    Background:

    • Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
    • Identifying key molecular players in DLBCL pathogenesis is crucial for developing effective therapies.

    Purpose of the Study:

    • To screen key genes, microRNAs (miRNAs), and transcription factors (TFs) associated with DLBCL.
    • To explore potential therapeutic targets for DLBCL progression.

    Main Methods:

    • Differential gene expression analysis using Limma on GSE56315 dataset.
    • Functional and pathway enrichment analyses of differentially expressed genes (DEGs).
    • Construction of functional interaction (FI) networks, TF-target-miRNA integrated networks.

    Main Results:

    • Identified 4,495 DEGs between DLBCL and normal tonsil samples.
    • Enriched pathways include chemokine signaling, phosphatidylinositol signaling, and RNA degradation.
    • Highlighted key miRNAs (miR-21-5p, miR-155, miR-17-5p), TF (STAT1), and DEGs (NUF2, CCR1, PIK3R1, SMC1A, FOXK1, CNOT6L) in integrated networks.

    Conclusions:

    • NUF2, CCR1, PIK3R1, SMC1A, FOXK1, and CNOT6L are potentially closely associated with DLBCL pathogenesis.
    • The identified molecular players represent potential therapeutic targets for DLBCL.