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Cytotoxic 8,9-seco-ent-kaurane diterpenoids from Croton kongensis
Shu-Qin Shi1,2, Yao-Yue Fan2, Cheng-Hui Xu2
1a Nano Science and Technology Institute, University of Science and Technology of China , Suzhou 215123 , China.
Abstract:
Chemical study on the ethanolic extract generated from the aerial parts of Croton kongensis led to the isolation of three new 8,9-seco-ent-kaurane diterpenoids, kongeniods A‒C (1‒3), together with seven known analogs (4-10). The structures of these compounds were assigned by spectroscopic data analysis. The vitro cytotoxic tests showed that compounds 1-3 exhibited strong activities against HL-60 cell lines with IC50 values of 0.47, 0.58, and 1.27 μM, respectively.

