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CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
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Hematopoietic Stem Cell Approaches to Cancer
Jennifer E Adair1, Sara P Kubek1, Hans-Peter Kiem1
1Stem Cell and Gene Therapy Program, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue N. D1-100 Seattle, WA 98109-1024, USA.
Hematology/Oncology Clinics of North America
|September 13, 2017
Summary
Hematopoietic stem cells (HSCs) can be engineered to enhance chemotherapy effectiveness against resistant tumors like glioblastoma. This modification also protects the blood system and can create cancer-fighting T cells.
Area of Science:
- Hematology
- Cancer Biology
- Immunotherapy
Background:
- Hematopoietic stem cells (HSCs) possess self-renewal and multi-lineage blood generation capabilities.
- Chemotherapy often causes myelosuppression, limiting treatment efficacy.
- Glioblastoma resistance to alkylating agents is mediated by methylguanine methyltransferase.
Purpose of the Study:
- To explore HSC modification for overcoming chemotherapy resistance.
- To investigate HSC-derived T cells for cancer immunotherapy.
- To enhance tumor sensitization and protect the hematopoietic system.
Main Methods:
- Discusses genetic modification of HSCs.
- Explores strategies for tumor sensitization.
- Outlines methods for generating tumor-specific T cells from HSCs.
Main Results:
- HSC modification can sensitize tumors to chemotherapy.
- Engineered HSCs can protect the hematopoietic system from chemotherapy toxicity.
- HSCs can be utilized to generate potent anti-tumor T cells.
Conclusions:
- HSC engineering offers a dual approach: enhancing chemotherapy and bolstering immunotherapy.
- This strategy holds promise for treating resistant cancers like glioblastoma.
- HSC-based therapies could revolutionize cancer treatment paradigms.
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